Lysostaphin from Staphylococcus staphylolyticus
Lysostaphin
CAS: 9011-93-2
Molecular Formula:
Lysostaphin from Staphylococcus staphylolyticus - Names and Identifiers
| Name | Lysostaphin |
| Synonyms | Lysostaphin LYSOSTAPHIN AFFINITY PURIFIED LYSOSTAPHIN ASEPTICALLY FILLED Lysostaphin from Staphylococcus staphylolyticus |
| CAS | 9011-93-2 |
| EINECS | 812-596-7 |
Lysostaphin from Staphylococcus staphylolyticus - Physico-chemical Properties
| Appearance | Morphological powder |
| Color | slightly brown |
| Merck | 13,5659 |
| Storage Condition | -20°C |
| MDL | MFCD00131556 |
| Physical and Chemical Properties | Bioactivity Lysostaphin an antistaphylococcal agent. Lysostaphin has inhibitory activity on glycine endopeptidase, endogenous β-N acetylated glucosidase, and N acetylated mural acylalanine amidase. |
| Use | Introduction: lysostaphin,Lys) is a protein produced by exogenous expression of lysozyme gene by gene cloning technology. It is a Zn2-dependent metalloproteinase with endopeptidase activity. It can specifically hydrolyze the cell wall of Staphylococcus aureus Gly pentapeptide bridging, rupture the cell wall of Staphylococcus aureus (especially MRSA), and achieve bactericidal bactericidal effect without drug resistance. As an antibacterial agent, it has great application potential in veterinary drugs and clinical fields. |
Lysostaphin from Staphylococcus staphylolyticus - Risk and Safety
| Safety Description | S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 3 |
| RTECS | OL5985000 |
| FLUKA BRAND F CODES | 10-21 |
| Toxicity | LD50 (7-day) in mice, rats (mg/kg): 820, 530 i.v. (Zygmunt) |
Lysostaphin from Staphylococcus staphylolyticus - Reference
| Reference Show more | 1. Su Yunfang, Li Yi, Qi Xuefeng, etc. Effect of lysostaphin on the structure of intestinal flora in mice [J]. Chinese Journal of Animal Husbandry and Veterinary abstracts, 2012, 040(010):1-8. 2. Xu Guochao, Guan Ruowei, Zhu Mingwu, Cao Xianqin, Li Bing, Guo Shan, Zhu Xiaoyan. Distribution and drug resistance mechanism of methicillin-resistant Staphylococcus aureus Hospital-acquired Infection [J]. Chinese Journal of pathogenic biology, 2020,15(04):477-482. 3. Su Yunfang, Li Yi, Qu Yanyan, et al. In vitro antibacterial activity of recombinant lysostaphin [J]. Progress in animal medicine, 2011, 32(009):19-22. 4. Tang, Cailin, et al. "Exploring antimicrobial mechanism of essential oil of amomilum Llung through through metal chemistry based on gas chromatography-mass spectroscopy in methicillin-resistant." Microbiological Research 242 (2021): 126608 5. [IF=4.181] Liu Baoguang et al."Prevalence, resistance pattern, and molecular characterization of Staphylococcus aureus isolates from healthy animals and sick populations in Henan Province, China."Gut Pathog. 2018 Dec;10(1):1-13 6. [IF=6.147] Jianghui Qin et al."The Bioinspired Facile Method to Efficiently Generate Diverse Proteinosomes with pH Switchable Permeability."Adv Mater Interfaces. 2020 Jul;7(14):2000329 7. [IF=5.415] Cailin Tang et al."Exploring antimicrobial mechanism of essential oil of Amomum villosum Lour through metabolomics based on gas chromatography-mass spectrometry in methicillin-resistant Staphylococcus aureus."Microbiol Res. 2021 Jan;242:126608 8. [IF=4.466] Yingshan Dong et al."Ciprofloxacin-Resistant Staphylococcus aureus Displays Enhanced Resistance and Virulence in Iron-Restricted Conditions. "J Proteome Res. 2021;20(5):2839-2850 Note: For some products, we can only provide some information, and we do not guarantee the authority of the information provided, for customer reference and communication purposes only. purpose: Biochemical Study. Bacteria with glycine peptide bond structure in cell wall such as Staphylococcus aureus are specifically degraded, and the purpose of sterilization is achieved by cracking the cell wall. storage conditions: -20 ℃ solubility: soluble in 50mmol/L tris-Cl influencing factors: hydroxymercury benzoic acid (PCMB), benzenesulfonyl chloride (PMSF), dithiothreitol (DTT) in the conditions of 1mmol/L, no significant effect on enzyme activity, Zn ions showed a certain degree of activation effect; Ba ions, Mn ions, Ca ions, mg ion and EDTA in the condition of 1mmol/L, showed a certain degree of inhibition of the enzyme of Staphylococcus aureus Properties: white or light yellow powder, is a zinc-containing metal protease, consisting of 246 amino acids. The nucleic acid for expression of the gene consists of 1486 nucleotides. solution storage method: the pH 7.5 enzyme solution (pH 5-8) was placed at 4 °c and was basically stable within 2-3 days. The optimum pH range of enzyme activity: 5-8. isoelectric point: 10.5-11.0. |
Lysostaphin from Staphylococcus staphylolyticus - Vitality definition
One unit will reduce the turbidity (A620) of a suspension of Staphylococcus aureus cells from 0.250 to 0.125 in 10 min at pH 7.5 at 37°C in a 6.0 ml reaction mixture。
Last Update：2023-08-16 21:32:38
Lysostaphin from Staphylococcus staphylolyticus - Method for Determination of enzyme activity
The determination was carried out by turbidimetry.
Last Update：2023-08-16 21:32:38
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